[HTML][HTML] Collagen dissolution by keratinocytes requires cell surface plasminogen activation and matrix metalloproteinase activity
S Netzel-Arnett, DJ Mitola, SS Yamada… - Journal of Biological …, 2002 - ASBMB
Matrix metalloproteinase-14 is required for degradation of fibrillar collagen by mesenchymal
cells. Here we show that keratinocytes use an alternative plasminogen and matrix
metalloproteinase-13-dependent pathway for dissolution of collagen fibrils. Primary
keratinocytes displayed an absolute requirement for serum to dissolve collagen. Dissolution
of collagen was abolished in plasminogen-depleted serum and could be restored by the
exogenous addition of plasminogen. Both plasminogen activator inhibitor-1 and tissue …
cells. Here we show that keratinocytes use an alternative plasminogen and matrix
metalloproteinase-13-dependent pathway for dissolution of collagen fibrils. Primary
keratinocytes displayed an absolute requirement for serum to dissolve collagen. Dissolution
of collagen was abolished in plasminogen-depleted serum and could be restored by the
exogenous addition of plasminogen. Both plasminogen activator inhibitor-1 and tissue …