[HTML][HTML] Glucagon-like peptide-1 receptor signaling modulates β cell apoptosis
Glucagon-like peptide-1 (GLP-1) stimulates insulin secretion and augments β cell mass via
activation of β cell proliferation and islet neogenesis. We examined whether GLP-1 receptor
signaling modifies the cellular susceptibility to apoptosis. Mice administered streptozotocin
(STZ), an agent known to induce β cell apoptosis, exhibit sustained improvement in glycemic
control and increased levels of plasma insulin with concomitant administration of the GLP-1
agonist exendin-4 (Ex-4). Blood glucose remained significantly lower for weeks after …
activation of β cell proliferation and islet neogenesis. We examined whether GLP-1 receptor
signaling modifies the cellular susceptibility to apoptosis. Mice administered streptozotocin
(STZ), an agent known to induce β cell apoptosis, exhibit sustained improvement in glycemic
control and increased levels of plasma insulin with concomitant administration of the GLP-1
agonist exendin-4 (Ex-4). Blood glucose remained significantly lower for weeks after …