The role of CD40–CD40 ligand (CD154) interactions in immunoglobulin light chain repertoire generation and somatic mutation
NL Monson, SJ Foster, HP Brezinschek… - Clinical …, 2001 - Elsevier
To determine whether CD40 ligation influences the molecular and selective mechanisms
that govern the development of the human Ig light chain repertoire, analysis of the Vκ and Vλ
repertoires of CD19+ B cells obtained from a patient with X-linked hyper IgM syndrome
(XHIM) and a nonfunctional CD154 was carried out. The nonproductive Vκ and Vλ
repertoires were largely comparable to that of the normals with respect to V gene and J
segment distribution as well as CDR3 length and VLJL joint complexity. Comparison of the …
that govern the development of the human Ig light chain repertoire, analysis of the Vκ and Vλ
repertoires of CD19+ B cells obtained from a patient with X-linked hyper IgM syndrome
(XHIM) and a nonfunctional CD154 was carried out. The nonproductive Vκ and Vλ
repertoires were largely comparable to that of the normals with respect to V gene and J
segment distribution as well as CDR3 length and VLJL joint complexity. Comparison of the …