Transforming growth factor-β in human glomerular injury
H Peters, NA Noble, WA Border - Current Opinion in Nephrology …, 1997 - journals.lww.com
H Peters, NA Noble, WA Border
Current Opinion in Nephrology and Hypertension, 1997•journals.lww.comOverexpression of the cytokine transforming growth factor-[beta] has been identified as the
key mediator of chronic progressive kidney fibrosis in experimental and human kidney
diseases. The renoprotective effects of angiotensin II blockade and low-protein diets have
recently been linked to downregulation of transforming growth factor-[beta] production.
Neutralizing the actions of transforming growth factor-[beta] by decorin gene therapy
appears to be a highly effective new approach in the treatment of renal fibrosis.
key mediator of chronic progressive kidney fibrosis in experimental and human kidney
diseases. The renoprotective effects of angiotensin II blockade and low-protein diets have
recently been linked to downregulation of transforming growth factor-[beta] production.
Neutralizing the actions of transforming growth factor-[beta] by decorin gene therapy
appears to be a highly effective new approach in the treatment of renal fibrosis.
Abstract
: Overexpression of the cytokine transforming growth factor-[beta] has been identified as the key mediator of chronic progressive kidney fibrosis in experimental and human kidney diseases. The renoprotective effects of angiotensin II blockade and low-protein diets have recently been linked to downregulation of transforming growth factor-[beta] production. Neutralizing the actions of transforming growth factor-[beta] by decorin gene therapy appears to be a highly effective new approach in the treatment of renal fibrosis.
Lippincott Williams & Wilkins