Differential role of IκB kinase 1 and 2 in primary rat hepatocytes
RF Schwabe, BL Bennett, AM Manning, DA Brenner - Hepatology, 2001 - Elsevier
Nuclear factor-κB (NF-κB) protects hepatocytes from undergoing apoptosis during
embryonic development and during liver regeneration. Activation of NF-κB is mediated
through phosphorylation of its inhibitor, IκB, by a kinase complex that contains 2 IκB kinases.
We analyzed the differential role of IκB kinase 1 (IKK1) and IκB kinase 2 (IKK2) in tumor
necrosis factor α (TNF-α)-and interleukin-1β (IL-1β)-mediated NF-κB activation in primary rat
hepatocytes. Maximal induction of IKK activity was observed 5 minutes after TNF-α and 15 …
embryonic development and during liver regeneration. Activation of NF-κB is mediated
through phosphorylation of its inhibitor, IκB, by a kinase complex that contains 2 IκB kinases.
We analyzed the differential role of IκB kinase 1 (IKK1) and IκB kinase 2 (IKK2) in tumor
necrosis factor α (TNF-α)-and interleukin-1β (IL-1β)-mediated NF-κB activation in primary rat
hepatocytes. Maximal induction of IKK activity was observed 5 minutes after TNF-α and 15 …