A high frequency of mtDNA polymorphisms in HeLa cell sublines
C Herrnstadt, G Preston, R Andrews, P Chinnery… - Mutation Research …, 2002 - Elsevier
The complete mtDNA sequences from the uncloned “founder” HeLa cells and from five
sublines have been determined. These sequences all carry a common “core” of 38 single
basepair alterations relative to the revised Cambridge Reference Sequence (CRS). The
HeLa mitochondrial genome is of African descent and it is a member of the African L3
haplogroup. The sequence of the HeLa mtDNA resolves the uncertainty surrounding the
mosaic composition of the original CRS for human mtDNA. Most importantly, we detected a …
sublines have been determined. These sequences all carry a common “core” of 38 single
basepair alterations relative to the revised Cambridge Reference Sequence (CRS). The
HeLa mitochondrial genome is of African descent and it is a member of the African L3
haplogroup. The sequence of the HeLa mtDNA resolves the uncertainty surrounding the
mosaic composition of the original CRS for human mtDNA. Most importantly, we detected a …