Patterns of risk in first-degree relatives of patients with Alzheimer's disease
JM Silverman, G Li, ML Zaccario… - Archives of General …, 1994 - jamanetwork.com
Background: Although an increased cumulative risk for primary progressive dementia (PPD)
has been repeatedly demonstrated in relatives of probands with Alzheimer's disease (AD),
an examination of their rates of illness at different ages has not been previously undertaken.
Such an examination might reveal possible age-related characteristics associated with a
more familial variety of AD. Methods: Using family history interviews and survival analysis,
the cumulative risk for and 5-year age-specific hazard rates of PPD were assessed in the …
has been repeatedly demonstrated in relatives of probands with Alzheimer's disease (AD),
an examination of their rates of illness at different ages has not been previously undertaken.
Such an examination might reveal possible age-related characteristics associated with a
more familial variety of AD. Methods: Using family history interviews and survival analysis,
the cumulative risk for and 5-year age-specific hazard rates of PPD were assessed in the …