[HTML][HTML] Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation: a role for the TSC2 tumor suppressor gene in pulmonary …
EA Goncharova, DA Goncharov, A Eszterhas… - Journal of Biological …, 2002 - ASBMB
Although the cellular functions ofTSC2 and its protein product, tuberin, are not known,
somatic mutations in the TSC2 tumor suppressor gene are associated with tumor
development in lymphangioleiomyomatosis (LAM). We found that ribosomal protein S6 (S6),
which exerts translational control of protein synthesis and is required for cell growth, is
hyperphosphorylated in the smooth muscle-like cell lesions of LAM patients compared with
smooth muscle cells from normal human blood vessels and trachea. Smooth muscle (SM) …
somatic mutations in the TSC2 tumor suppressor gene are associated with tumor
development in lymphangioleiomyomatosis (LAM). We found that ribosomal protein S6 (S6),
which exerts translational control of protein synthesis and is required for cell growth, is
hyperphosphorylated in the smooth muscle-like cell lesions of LAM patients compared with
smooth muscle cells from normal human blood vessels and trachea. Smooth muscle (SM) …