Expression of the plasminogen activator system and the inhibitors PAI-1 and PAI-2 in posttraumatic lesions of the CNS and brain injuries following dramatic circulatory …
K Dietzmann, P Bossanyi, D Krause, H Wittig… - … -Research and Practice, 2000 - Elsevier
Plasminogen activators as inducible extracellular serine proteases are involved in a variety
of processes, such as the degradation of brain structures. In regions of brain degradation, an
increase in the expression of genes encoding cytokines and proteinases has recently been
demonstrated. We tested the hypothesis, whether the plasminogen activator system as well
as the Plasminogen activator inhibitors are expressed and possibly involved in a proteolytic
cascade that breaks down the extracellular matrix as a result of ischemic or posttraumatic …
of processes, such as the degradation of brain structures. In regions of brain degradation, an
increase in the expression of genes encoding cytokines and proteinases has recently been
demonstrated. We tested the hypothesis, whether the plasminogen activator system as well
as the Plasminogen activator inhibitors are expressed and possibly involved in a proteolytic
cascade that breaks down the extracellular matrix as a result of ischemic or posttraumatic …