[HTML][HTML] Dermatan sulfate released after injury is a potent promoter of fibroblast growth factor-2 function
SF Penc, B Pomahac, T Winkler, RA Dorschner… - Journal of Biological …, 1998 - ASBMB
Proteoglycans have been shown in vitro to bind multiple components of the cellular
microenvironment that function during wound healing. To study the composition and function
of these molecules when derived from anin vivo source, soluble proteoglycans released into
human wound fluid were characterized and evaluated for influence on fibroblast growth
factor-2 activity. Immunoblot analysis of wound fluid revealed the presence of syndecan-1,
syndecan-4, glypican, decorin, perlecan, and versican. Sulfated glycosaminoglycan …
microenvironment that function during wound healing. To study the composition and function
of these molecules when derived from anin vivo source, soluble proteoglycans released into
human wound fluid were characterized and evaluated for influence on fibroblast growth
factor-2 activity. Immunoblot analysis of wound fluid revealed the presence of syndecan-1,
syndecan-4, glypican, decorin, perlecan, and versican. Sulfated glycosaminoglycan …