Role of C–KitReceptor Tyrosine Kinase in Development of Oval Cells in the Rat 2–Acetylaminofluorene/Partial Hepatectomy Model
S Matsusaka, T Tsujimura, A Toyosaka, K Nakasho… - Hepatology, 1999 - journals.lww.com
Oval cells that develop in the rat 2–acetylaminofluorene/partial hepatectomy (AAF/PH)
model express the c–kit receptor tyrosine kinase (KIT) and its ligand, stem cell factor (SCF).
We investigated the role of the SCF/KIT system in the development of oval cells using Ws/Ws
rats, whose c–kit kinase activity was severely impaired owing to a small deletion in the
kinase domain. On days 7, 9, and 13 after PH in the AAF/PH model, the development of oval
cells was remarkably suppressed in Ws/Ws rats when compared with that of the control …
model express the c–kit receptor tyrosine kinase (KIT) and its ligand, stem cell factor (SCF).
We investigated the role of the SCF/KIT system in the development of oval cells using Ws/Ws
rats, whose c–kit kinase activity was severely impaired owing to a small deletion in the
kinase domain. On days 7, 9, and 13 after PH in the AAF/PH model, the development of oval
cells was remarkably suppressed in Ws/Ws rats when compared with that of the control …