Fas, a death domain-containing member of the tumor necrosis factor receptor family and its
ligand FasL have been predominantly studied with respect to their capability to induce cell
death. However, a few studies indicate a proliferation-inducing signaling activity of these
molecules too. We describe here a novel signaling pathway of FasL and the tumor necrosis
factor-related apoptosis-inducing ligand (TRAIL) that triggers transcriptional activation of the
proto-oncogene c-fos, a typical target gene of mitogenic pathways. FasL-and TRAIL …