[HTML][HTML] Nitric oxide-induced S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase inhibits enzymatic activity and increases endogenous ADP-ribosylation.
LM y Vedia, B McDonald, B Reep, B Brüne… - Journal of Biological …, 1992 - Elsevier
Using conditions that produced chronic inflammation in rat liver, we were able to find a
correlation between induction of nitric oxide production and inhibition of glyceraldehyde-3-
phosphate dehydrogenase (GAPDH; EC 1.2. 1.12). This enzyme is a tetramer composed of
identical M (r) 37,000 subunits. The tetramer contains 16 thiol groups, four of which are
essential for enzymatic activity. Our information indicates that four thiol groups are S-
nitrosylated by exposure to authentic nitric oxide (NO) gas. Furthermore, NO decreased …
correlation between induction of nitric oxide production and inhibition of glyceraldehyde-3-
phosphate dehydrogenase (GAPDH; EC 1.2. 1.12). This enzyme is a tetramer composed of
identical M (r) 37,000 subunits. The tetramer contains 16 thiol groups, four of which are
essential for enzymatic activity. Our information indicates that four thiol groups are S-
nitrosylated by exposure to authentic nitric oxide (NO) gas. Furthermore, NO decreased …
Nitric oxide-induced S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase inhibits enzymatic activity and increases endogenous ADP-ribosylation
L Molina y Vedia, B McDonald, B Reep… - Journal of Biological …, 1992 - hero.epa.gov
Using conditions that produced chronic inflammation in rat liver, we were able to find a
correlation between induction of nitric oxide production and inhibition of glyceraldehyde-3-
phosphate dehydrogenase (GAPDH; EC 1.2. 1.12). This enzyme is a tetramer composed of
identical M (r) 37,000 subunits. The tetramer contains 16 thiol groups, four of which are
essential for enzymatic activity. Our information indicates that four thiol groups are S-
nitrosylated by exposure to authentic nitric oxide (NO) gas. Furthermore, NO decreased …
correlation between induction of nitric oxide production and inhibition of glyceraldehyde-3-
phosphate dehydrogenase (GAPDH; EC 1.2. 1.12). This enzyme is a tetramer composed of
identical M (r) 37,000 subunits. The tetramer contains 16 thiol groups, four of which are
essential for enzymatic activity. Our information indicates that four thiol groups are S-
nitrosylated by exposure to authentic nitric oxide (NO) gas. Furthermore, NO decreased …