Airways remodeling is a distinctive feature of asthma and is related to severity of disease

A Chetta, A Foresi, M Del Donno, G Bertorelli, A Pesci… - Chest, 1997 - Elsevier
Purpose Airways remodeling, evaluated as the subepithelial layer thickness, was compared
in asthmatic patients with that of healthy subjects, and was related to clinical grading of
disease, presence of atopy, and length of asthmatic history. Subjects and methods Thirty-
four patients with stable asthma (mean age±SD: 26.5±9.2 years; 10 female) treated with only
inhaled β 2-agonists and eight healthy volunteers (mean age±SD: 24.6±2.5 years; four
female) were recruited for the study. Twenty-seven of 34 asthmatics had atopy. Eleven …