Expression of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin immunoreactivity in asthmatic airways and its relationship to …

M Hoshino, M Takahashi, N Aoike - Journal of Allergy and Clinical …, 2001 - Elsevier
Background: Angiogenesis is a prerequisite for airway remodeling in bronchial asthma.
Several growth factors may play important roles in inflammation and angiogenesis through
effects on inflammatory cell infiltration or neovascularization. Objective: We sought to
compare bronchial vascularity and expression of vascular endothelial growth factor (VEGF),
basic fibroblast growth factor (bFGF), and angiogenin in bronchial biopsy specimens from
asthmatic and healthy control subjects. Methods: Bronchial biopsy specimens were obtained …