[PDF][PDF] From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels
WA Catterall - Neuron, 2000 - cell.com
WA Catterall
Neuron, 2000•cell.comFrom Ionic Currents to Molecular Review Mechanisms: The Structure and Function of
Voltage-Gated Sodium Channels tetrodotoxin binding activity and a protein of 270 kDa
(Agnew et al., 1980). Subsequent purification studies showed that the sodium channel from
mammalian brain is a complex of α (260 kDa), ß1 (36 kDa), and ß2 (33 kDa) subunits
(Hartshorne and Catterall, 1981; Hartshorne et
Voltage-Gated Sodium Channels tetrodotoxin binding activity and a protein of 270 kDa
(Agnew et al., 1980). Subsequent purification studies showed that the sodium channel from
mammalian brain is a complex of α (260 kDa), ß1 (36 kDa), and ß2 (33 kDa) subunits
(Hartshorne and Catterall, 1981; Hartshorne et
From Ionic Currents to Molecular Review Mechanisms: The Structure and Function of Voltage-Gated Sodium Channels tetrodotoxin binding activity and a protein of 270 kDa (Agnew et al., 1980). Subsequent purification studies showed that the sodium channel from mammalian brain is a complex of α (260 kDa), ß1 (36 kDa), and ß2 (33 kDa) subunits (Hartshorne and Catterall, 1981; Hartshorne et
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