[HTML][HTML] Prostaglandin F2α (PGF2α) and the isoprostane, 8, 12-iso-isoprostane F2α-III, induce cardiomyocyte hypertrophy: differential activation of downstream …
P Kunapuli, JA Lawson, JA Rokach, JL Meinkoth… - Journal of Biological …, 1998 - ASBMB
Prostaglandin receptors may be activated by their cognate ligand or by free radical
catalyzed isoprostanes, products of arachidonic acid peroxidation. For example,
prostaglandin F 2α (PGF 2α) causes hypertrophy of neonatal rat ventricular myocytes, via
the PGF 2α receptor (FP). However, the FP may also be activated by the isoprostane, 8, 12-
iso-iPF 2α-III (Kunapuli, P., Lawson, JA, Rokach, J., and FitzGerald, GA (1997) J. Biol. Chem.
272, 27147–27154). Both ligands induce myocyte hypertrophy with overlapping potencies …
catalyzed isoprostanes, products of arachidonic acid peroxidation. For example,
prostaglandin F 2α (PGF 2α) causes hypertrophy of neonatal rat ventricular myocytes, via
the PGF 2α receptor (FP). However, the FP may also be activated by the isoprostane, 8, 12-
iso-iPF 2α-III (Kunapuli, P., Lawson, JA, Rokach, J., and FitzGerald, GA (1997) J. Biol. Chem.
272, 27147–27154). Both ligands induce myocyte hypertrophy with overlapping potencies …