[HTML][HTML] Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling
Bone morphogenetic proteins (BMP) transduce their signals into the cell through a family of
mediator proteins known as Smads. Upon phosphorylation by the BMP receptors, Smad1
interacts with Smad4 and translocates into the nucleus where the complex recruits DNA-
binding protein (s) to activate specific gene transcription. However, the DNA-binding protein
(s) involved in BMP signaling has not been identified. Using a yeast two-hybrid approach,
we found that Smad1 interacts with Hoxc-8, a homeodomain transcription factor. The …
mediator proteins known as Smads. Upon phosphorylation by the BMP receptors, Smad1
interacts with Smad4 and translocates into the nucleus where the complex recruits DNA-
binding protein (s) to activate specific gene transcription. However, the DNA-binding protein
(s) involved in BMP signaling has not been identified. Using a yeast two-hybrid approach,
we found that Smad1 interacts with Hoxc-8, a homeodomain transcription factor. The …