Leucine/isoleucine zipper coordination of ion channel macromolecular signaling complexes in the heart: roles in inherited arrhythmias

RS Kass, J Kurokawa, SO Marx, AR Marks - Trends in cardiovascular …, 2003 - Elsevier
The sympathetic nervous system controls the force and rate of contraction of the heart. The
rapid response to stress and exercise mediated by increased sympathetic nervous system
(SNS) activity requires the coordinated regulation of several ion channels in response to
activation of β-adrenergic receptors. The microenvironment of target channels is mediated
by the assembly of macromolecular signaling complexes in which targeting proteins recruit
phosphatases and kinases and in turn bind directly to the channel protein via highly …