[HTML][HTML] Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer
L Leyns, T Bouwmeester, SH Kim, S Piccolo… - Cell, 1997 - cell.com
L Leyns, T Bouwmeester, SH Kim, S Piccolo, EM De Robertis
Cell, 1997•cell.comFrzb-1 is a secreted protein containing a domain similar to the putative Wnt-binding region of
the frizzled family of transmembrane receptors. Frzb-1 is widely expressed in adult
mammalian tissues. In the Xenopus gastrula, it is expressed and regulated as a typical
Spemann organizer component. Injection of frzb-1 mRNA blocks expression of XMyoD
mRNA and leads to embryos with enlarged heads and shortened trunks. Frzb-1 antagonizes
the effects of Xwnt-8 ectopic expression in a non-cell-autonomous manner. Cultured cells …
the frizzled family of transmembrane receptors. Frzb-1 is widely expressed in adult
mammalian tissues. In the Xenopus gastrula, it is expressed and regulated as a typical
Spemann organizer component. Injection of frzb-1 mRNA blocks expression of XMyoD
mRNA and leads to embryos with enlarged heads and shortened trunks. Frzb-1 antagonizes
the effects of Xwnt-8 ectopic expression in a non-cell-autonomous manner. Cultured cells …
Abstract
Frzb-1 is a secreted protein containing a domain similar to the putative Wnt-binding region of the frizzled family of transmembrane receptors. Frzb-1 is widely expressed in adult mammalian tissues. In the Xenopus gastrula, it is expressed and regulated as a typical Spemann organizer component. Injection of frzb-1 mRNA blocks expression of XMyoD mRNA and leads to embryos with enlarged heads and shortened trunks. Frzb-1 antagonizes the effects of Xwnt-8 ectopic expression in a non-cell-autonomous manner. Cultured cells transfected with a membrane-tethered form of Wnt-1 bind epitope-tagged Frzb-1 in the 10−10 M range. The results strengthen the view that the Spemann organizer is a source of secreted inhibitory factors.
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