[HTML][HTML] Alterations in thin filament regulation induced by a human cardiac troponin T mutant that causes dilated cardiomyopathy are distinct from those induced by …
P Robinson, M Mirza, A Knott, H Abdulrazzak… - Journal of Biological …, 2002 - ASBMB
We have compared the in vitroregulatory properties of recombinant human cardiac troponin
reconstituted using wild type troponin T with troponin containing the ΔLys-210 troponin T
mutant that causes dilated cardiomyopathy (DCM) and the R92Q troponin T known to cause
hypertrophic cardiomyopathy (HCM). Troponin containing ΔLys-210 troponin T inhibited
actin-tropomyosin-activated myosin subfragment-1 ATPase activity to the same extent as
wild type at pCa8. 5 (> 80%) but produced substantially less enhancement of ATPase …
reconstituted using wild type troponin T with troponin containing the ΔLys-210 troponin T
mutant that causes dilated cardiomyopathy (DCM) and the R92Q troponin T known to cause
hypertrophic cardiomyopathy (HCM). Troponin containing ΔLys-210 troponin T inhibited
actin-tropomyosin-activated myosin subfragment-1 ATPase activity to the same extent as
wild type at pCa8. 5 (> 80%) but produced substantially less enhancement of ATPase …