[HTML][HTML] Identification of a major subfamily of large hsp70-like proteins through the cloning of the mammalian 110-kDa heat shock protein
A major mammalian heat shock protein of 110 kDa (hsp110) has long been observed, but
has not been cloned. We have cloned the hamster cDNA for hsp110 and show that it
hybridizes on a Northern blot to a 3.5-kilobase heat-inducible message in hamster and
mouse. The hsp110 sequence was found to share an~ 30-33% amino acid identity with
members of the hsp70 family, most of which occurs in the conserved ATP-binding domain of
these molecules. In addition, five sequences were found to be highly similar to hsp110 …
has not been cloned. We have cloned the hamster cDNA for hsp110 and show that it
hybridizes on a Northern blot to a 3.5-kilobase heat-inducible message in hamster and
mouse. The hsp110 sequence was found to share an~ 30-33% amino acid identity with
members of the hsp70 family, most of which occurs in the conserved ATP-binding domain of
these molecules. In addition, five sequences were found to be highly similar to hsp110 …