Chemokines are a'complex superfamily of chemotactic cytokines mainly involved in immune
and inflammatory processes (1-3). The extravasation of leukocytes from the blood
compartment into tissues is best described as a multistep process in which multiple
molecules are at play in any given step. Among other, chemotactic cytokines playa crucial
role in this process and activation of chemotactic receptors on leukocytes is mandatory for
transmigration. Structurally, they are characterized by 4 conserVed Cys residues, the first 2 …