[HTML][HTML] Modification of the β2-adrenergic receptor to engineer a receptor-effector complex for gene therapy
KM Small, KM Brown, SL Forbes, SB Liggett - Journal of Biological …, 2001 - ASBMB
Depressed G-protein-coupled receptor (GPCR) signaling has been implicated as a
component of the pathophysiology of a number of complex diseases including heart failure
and asthma, and augmentation or restoration of signaling by various means has been
shown to improve organ function. Because some properties of native GPCRs are
disadvantageous for ectopic therapeutic expression, we utilized the β 2-adrenergic receptor
(β 2 AR) as a scaffold to construct a highly modified therapeutic receptor-effector complex …
component of the pathophysiology of a number of complex diseases including heart failure
and asthma, and augmentation or restoration of signaling by various means has been
shown to improve organ function. Because some properties of native GPCRs are
disadvantageous for ectopic therapeutic expression, we utilized the β 2-adrenergic receptor
(β 2 AR) as a scaffold to construct a highly modified therapeutic receptor-effector complex …