[HTML][HTML] Transgenic overexpression of β2-adrenergic receptors in airway smooth muscle alters myocyte function and ablates bronchial hyperreactivity
DW McGraw, SL Forbes, LA Kramer, DP Witte… - Journal of Biological …, 1999 - ASBMB
β 2-Adrenergic receptors (β 2 AR) act to relax airway smooth muscle and can serve to
counteract hyperresponsiveness, although the effect may not be ablative even in the
presence of exogenous agonist. Within this signaling cascade that ultimately transduces
smooth muscle relaxation, a significant" spare receptor" pool has been hypothesized to be
present in the airway. In order to modify the relationship between β 2 AR and downstream
effectors, transgenic mice (TG) were created overexpressing β 2 AR∼ 75-fold in airway …
counteract hyperresponsiveness, although the effect may not be ablative even in the
presence of exogenous agonist. Within this signaling cascade that ultimately transduces
smooth muscle relaxation, a significant" spare receptor" pool has been hypothesized to be
present in the airway. In order to modify the relationship between β 2 AR and downstream
effectors, transgenic mice (TG) were created overexpressing β 2 AR∼ 75-fold in airway …