[HTML][HTML] Interleukin-6 protects against Fas-mediated death by establishing a critical level of anti-apoptotic hepatic proteins FLIP, Bcl-2, and Bcl-xL
K Kovalovich, W Li, R DeAngelis… - Journal of Biological …, 2001 - ASBMB
Previous studies showed that following acute carbon tetrachloride (CCl 4) treatment,
interleukin-6 null (IL-6−/−) mice develop increased hepatocellular injury, defective
regeneration, delayed wound healing, and increased hepatocyte apoptosis. Pretreatment
with IL-6 prior to CCl 4 reduces injury, hepatocyte apoptosis, and accelerates regeneration
in both IL-6−/− and+/+ livers. To demonstrate whether IL-6 can prevent liver injury that
involves direct stimulation of hepatocyte apoptosis, IL-6−/− and+/+ mice were treated with …
interleukin-6 null (IL-6−/−) mice develop increased hepatocellular injury, defective
regeneration, delayed wound healing, and increased hepatocyte apoptosis. Pretreatment
with IL-6 prior to CCl 4 reduces injury, hepatocyte apoptosis, and accelerates regeneration
in both IL-6−/− and+/+ livers. To demonstrate whether IL-6 can prevent liver injury that
involves direct stimulation of hepatocyte apoptosis, IL-6−/− and+/+ mice were treated with …