Trafficking of major histocompatibility complex class II molecules through intracellular compartments containing HLA-DM
NF Robbins, C Hammond, LK Denzin, M Pan… - Human immunology, 1996 - Elsevier
The endosomal site (s) where MHC class II molecules become competent to bind antigenic
peptide has not been completely characterized. We identified endocytic compartments
through which newly synthesized MHC class II molecules move prior to their expression on
the plasma membrane. The compartments co-sediment with lysosomes in the most dense
regions of Percoll gradients. The appearance of proteolytic fragments of the invariant chain (I
chain), namely leupeptin-induced proteins (LIPs) and class-II-associated invariant chain …
peptide has not been completely characterized. We identified endocytic compartments
through which newly synthesized MHC class II molecules move prior to their expression on
the plasma membrane. The compartments co-sediment with lysosomes in the most dense
regions of Percoll gradients. The appearance of proteolytic fragments of the invariant chain (I
chain), namely leupeptin-induced proteins (LIPs) and class-II-associated invariant chain …