[HTML][HTML] Integrin-linked protein kinase regulates fibronectin matrix assembly, E-cadherin expression, and tumorigenicity
C Wu, SY Keightley, C Leung-Hagesteijn… - Journal of Biological …, 1998 - ASBMB
Fibronectin (Fn) matrix plays important roles in many biological processes including
morphogenesis and tumorigenesis. Recent studies have demonstrated a critical role of
integrin cytoplasmic domains in regulating Fn matrix assembly, implying that intracellular
integrin-binding proteins may be involved in controlling extracellular Fn matrix assembly. We
report here that overexpression of integrin-linked kinase (ILK), a newly identified
serine/threonine kinase that binds to the integrin β 1 cytoplasmic domain, dramatically …
morphogenesis and tumorigenesis. Recent studies have demonstrated a critical role of
integrin cytoplasmic domains in regulating Fn matrix assembly, implying that intracellular
integrin-binding proteins may be involved in controlling extracellular Fn matrix assembly. We
report here that overexpression of integrin-linked kinase (ILK), a newly identified
serine/threonine kinase that binds to the integrin β 1 cytoplasmic domain, dramatically …