[HTML][HTML] Thyroxine promotes association of mitogen-activated protein kinase and nuclear thyroid hormone receptor (TR) and causes serine phosphorylation of TR
PJ Davis, A Shih, HY Lin, LJ Martino… - Journal of Biological …, 2000 - ASBMB
Activated nongenomically byl-thyroxine (T 4), mitogen-activated protein kinase (MAPK)
complexed in 10–20 min with endogenous nuclear thyroid hormone receptor (TRβ1 or TR)
in nuclear fractions of 293T cells, resulting in serine phosphorylation of TR. Treatment of
cells with the MAPK kinase inhibitor, PD 98059, prevented both T 4-induced nuclear MAPK-
TR co-immunoprecipitation and serine phosphorylation of TR. T 4 treatment caused
dissociation of TR and SMRT (silencing mediator of retinoid and thyroid hormone receptor) …
complexed in 10–20 min with endogenous nuclear thyroid hormone receptor (TRβ1 or TR)
in nuclear fractions of 293T cells, resulting in serine phosphorylation of TR. Treatment of
cells with the MAPK kinase inhibitor, PD 98059, prevented both T 4-induced nuclear MAPK-
TR co-immunoprecipitation and serine phosphorylation of TR. T 4 treatment caused
dissociation of TR and SMRT (silencing mediator of retinoid and thyroid hormone receptor) …