[HTML][HTML] Thyroid hormone receptor DNA binding is required for both positive and negative gene regulation
N Shibusawa, AN Hollenberg, FE Wondisford - Journal of Biological …, 2003 - ASBMB
The β isoform of thyroid hormone receptor (TR-β) has a key role in the feedback regulation
of the hypothalamic-pituitary-thyroid (HPT) axis. The mechanism of trans-repression of the
hypothalamic thyrotropin-releasing hormone (TRH) and pituitary thyroid-stimulating
hormone (TSH) subunit genes, however, remains poorly understood. A number of distinct
mechanisms for TR-β-mediated negative regulation by thyroid hormone have been
proposed, including those that require and do not require DNA binding. To clarify the …
of the hypothalamic-pituitary-thyroid (HPT) axis. The mechanism of trans-repression of the
hypothalamic thyrotropin-releasing hormone (TRH) and pituitary thyroid-stimulating
hormone (TSH) subunit genes, however, remains poorly understood. A number of distinct
mechanisms for TR-β-mediated negative regulation by thyroid hormone have been
proposed, including those that require and do not require DNA binding. To clarify the …