[HTML][HTML] Modification of alternative splicing of Bcl-x Pre-mRNA in prostate and breast cancer cells: analysis of apoptosis and cell death
DR Mercatante, CD Bortner, JA Cidlowski… - Journal of Biological …, 2001 - ASBMB
There is ample evidence that deregulation of apoptosis results in the development,
progression, and/or maintenance of cancer. Since many apoptotic regulatory genes (eg bcl-
x) code for alternatively spliced protein variants with opposing functions, the manipulation of
alternative splicing presents a unique way of regulating the apoptotic response. Here we
have targeted oligonucleotides antisense to the 5′-splice site ofbcl-x L, an anti-apoptotic
gene that is overexpressed in various cancers, and shifted the splicing pattern of Bcl-x pre …
progression, and/or maintenance of cancer. Since many apoptotic regulatory genes (eg bcl-
x) code for alternatively spliced protein variants with opposing functions, the manipulation of
alternative splicing presents a unique way of regulating the apoptotic response. Here we
have targeted oligonucleotides antisense to the 5′-splice site ofbcl-x L, an anti-apoptotic
gene that is overexpressed in various cancers, and shifted the splicing pattern of Bcl-x pre …