Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis

CM Coopersmith, PE Stromberg, WM Dunne, CG Davis… - Jama, 2002 - jamanetwork.com
ContextIncreased intestinal epithelial apoptosis is present in both human autopsy studies
and animal models of sepsis. Whether altering gut apoptosis decreases mortality in sepsis
induced by pathogenic bacteria outside the gut is unknown. ObjectiveTo determine if
decreasing levels of intestinal cell death improves survival in a murine model of
Pseudomonas aeruginosa pneumonia–induced sepsis. Design and MaterialsProspective
study in which transgenic mice that overexpress the antiapoptotic protein Bcl-2 in their …