The role of cytotoxicity in lymphocyte homeostasis

G de Saint Basile, A Fischer - Current opinion in immunology, 2001 - Elsevier
G de Saint Basile, A Fischer
Current opinion in immunology, 2001Elsevier
Several human inherited immune disorders lead to the same fatal lymphoproliferative
syndrome, called the hemophagocytic syndrome. Through defective perforin expression or
transport, these disorders highlight the determinant role of the secretory cytotoxic pathway in
the regulation of the immune response and in lymphocyte homeostasis. In addition, new
effectors of this secretory pathway have been identified.
Several human inherited immune disorders lead to the same fatal lymphoproliferative syndrome, called the hemophagocytic syndrome. Through defective perforin expression or transport, these disorders highlight the determinant role of the secretory cytotoxic pathway in the regulation of the immune response and in lymphocyte homeostasis. In addition, new effectors of this secretory pathway have been identified.
Elsevier