[HTML][HTML] The Slp homology domain of synaptotagmin-like proteins 1–4 and Slac2 functions as a novel Rab27A binding domain

TS Kuroda, M Fukuda, H Ariga, K Mikoshiba - Journal of biological …, 2002 - ASBMB
rab27A, which encodes a small GTP-binding protein, was recently identified as a gene in
which mutations caused human hemophagocytic syndrome (Griscelli syndrome) andashen
mice, which exhibit defects in melanosome transport as well as in regulated granule
exocytosis in cytotoxic T lymphocytes. However, little is known about the molecular
mechanism of Rab27A-dependent membrane trafficking or the specific effector molecules of
Rab27A. In this study, we discovered that the Slp (synaptotagmin-like protein) homology …