[HTML][HTML] The Hepatitis Delta Virus Large Antigen Is Farnesylated Both in Vitro and in Animal Cells (∗)
JC Otto, PJ Casey - Journal of Biological Chemistry, 1996 - ASBMB
The hepatitis delta virus large antigen (lHDAg) is a virally encoded protein that contains a
prenylation signal sequence at its carboxyl terminus consisting of the tetrapeptide Cys-Arg-
Pro-Gln. Although the presence of the Gln as the COOH-terminal residue generally specifies
addition of the 15-carbon farnesyl isoprenoid, earlier reports had suggested that the protein
is modified by the 20-carbon geranylgeranyl. The prenylation of lHDAg was examined in
vitro using a fusion protein between glutathione S-transferase and the COOH-terminal 117 …
prenylation signal sequence at its carboxyl terminus consisting of the tetrapeptide Cys-Arg-
Pro-Gln. Although the presence of the Gln as the COOH-terminal residue generally specifies
addition of the 15-carbon farnesyl isoprenoid, earlier reports had suggested that the protein
is modified by the 20-carbon geranylgeranyl. The prenylation of lHDAg was examined in
vitro using a fusion protein between glutathione S-transferase and the COOH-terminal 117 …