[HTML][HTML] Cloning and targeted deletion of the mouse fetuin gene
W Jahnen-Dechent, T Schinke, A Trindl… - Journal of Biological …, 1997 - ASBMB
We proposed that the α 2-Heremans Schmid glycoprotein/fetuin family of serum proteins
inhibits unwanted mineralization. To test this hypothesis in animals, we cloned the mouse
fetuin gene and generated mice lacking fetuin. The gene consists of seven exons and six
introns. The cystatin-like domains D1 and D2 of mouse fetuin are encoded by three exons
each, whereas a single terminal exon encodes the carboxyl-terminal domain D3. The
promoter structure is well conserved between rat and mouse fetuin genes within the regions …
inhibits unwanted mineralization. To test this hypothesis in animals, we cloned the mouse
fetuin gene and generated mice lacking fetuin. The gene consists of seven exons and six
introns. The cystatin-like domains D1 and D2 of mouse fetuin are encoded by three exons
each, whereas a single terminal exon encodes the carboxyl-terminal domain D3. The
promoter structure is well conserved between rat and mouse fetuin genes within the regions …