Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes.

BM Spiegelman, L Choy, GS Hotamisligil, RA Graves… - 1993 - cabidigitallibrary.org
1993cabidigitallibrary.org
As excessive adipose tissue (obesity) is a risk factor for hypertension, certain neoplasms
and diabetes, research on the regulation of adipocyte gene expression in cell differentiation
is reviewed with sections on: established cell lines; regulation of differentiation-related
genes; mechanisms of differentiation-linked gene expression; transcriptional control; and the
aP2 enhancer. A small number of genes have been shown to be dysregulated in the
adipose tissue of obese animals. The mechanisms behind these dysregulations and their …
Abstract
As excessive adipose tissue (obesity) is a risk factor for hypertension, certain neoplasms and diabetes, research on the regulation of adipocyte gene expression in cell differentiation is reviewed with sections on: established cell lines; regulation of differentiation-related genes; mechanisms of differentiation-linked gene expression; transcriptional control; and the aP2 enhancer. A small number of genes have been shown to be dysregulated in the adipose tissue of obese animals. The mechanisms behind these dysregulations and their role in systemic disease are discussed.
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