[HTML][HTML] Alternative T-cell costimulatory pathways in transplant rejection and tolerance induction: hierarchy or redundancy?
AD Salama, MH Sayegh - American Journal of Transplantation, 2003 - Elsevier
Since the original proposal of a two-signal model for lymphocyte activation (1), it has
become firmly established that costimulatory signals mediated primarily via the conventional
CD28-B7 and CD154-CD40 pathways, are necessary for full T-cell activation and play a
crucial role in mediating allograft rejection (2). In several transplantation models, CD28-B7
or CD154-CD40 blockade has been shown to prevent acute rejection, induce long-term
allograft survival and prevent the development and progression of chronic rejection …
become firmly established that costimulatory signals mediated primarily via the conventional
CD28-B7 and CD154-CD40 pathways, are necessary for full T-cell activation and play a
crucial role in mediating allograft rejection (2). In several transplantation models, CD28-B7
or CD154-CD40 blockade has been shown to prevent acute rejection, induce long-term
allograft survival and prevent the development and progression of chronic rejection …