[HTML][HTML] SarA, a global regulator of virulence determinants instaphylococcus aureus, binds to a conserved motif essential for sar-dependent gene regulation
Y Chien, AC Manna, SJ Projan, AL Cheung - Journal of Biological …, 1999 - ASBMB
The expression of many virulence determinants inStaphylococcus aureus including α-
hemolysin-, protein A-, and fibronectin-binding proteins is controlled by global regulatory loci
such as sar and agr. In addition to controlling target gene expression via agr (eg α-
hemolysin), the sar locus can also regulate target gene transcription via agr-independent
mechanisms. In particular, we have found that SarA, the major regulatory protein encoded
within sar, binds to a conserved sequence, homologous to the SarA-binding site on the …
hemolysin-, protein A-, and fibronectin-binding proteins is controlled by global regulatory loci
such as sar and agr. In addition to controlling target gene expression via agr (eg α-
hemolysin), the sar locus can also regulate target gene transcription via agr-independent
mechanisms. In particular, we have found that SarA, the major regulatory protein encoded
within sar, binds to a conserved sequence, homologous to the SarA-binding site on the …