[HTML][HTML] Matrix metalloproteinase activity inactivates the CXC chemokine stromal cell-derived factor-1
GA McQuibban, GS Butler, JH Gong, L Bendall… - Journal of Biological …, 2001 - ASBMB
Chemokines provide directional cues for leukocyte migration and activation that are
essential for normal leukocytic trafficking and for host responses during processes such as
inflammation, infection, and cancer. Recently we reported that matrix metalloproteinases
(MMPs) modulate the activity of the CC chemokine monocyte chemoattractant protein-3 by
selective proteolysis to release the N-terminal tetrapeptide. Here we report the N-terminal
processing, also at position 4–5, of the CXC chemokines stromal cell-derived factor (SDF) …
essential for normal leukocytic trafficking and for host responses during processes such as
inflammation, infection, and cancer. Recently we reported that matrix metalloproteinases
(MMPs) modulate the activity of the CC chemokine monocyte chemoattractant protein-3 by
selective proteolysis to release the N-terminal tetrapeptide. Here we report the N-terminal
processing, also at position 4–5, of the CXC chemokines stromal cell-derived factor (SDF) …