Chemokines—chemotactic cytokines that mediate inflammation

AD Luster - New England Journal of Medicine, 1998 - Mass Medical Soc
AD Luster
New England Journal of Medicine, 1998Mass Medical Soc
The attraction of leukocytes to tissues is essential for inflammation and the host response to
infection. The process is controlled by chemokines, which are chemotactic cytokines. This
review introduces the burgeoning family of cytokines, with special emphasis on their role in
the pathophysiology of disease and their potential as targets for therapy. Structure and
Function of Chemokines Over 40 chemokines have been identified to date, most of them in
the past few years. The relations among chemokines were not initially appreciated, which …
The attraction of leukocytes to tissues is essential for inflammation and the host response to infection. The process is controlled by chemokines, which are chemotactic cytokines. This review introduces the burgeoning family of cytokines, with special emphasis on their role in the pathophysiology of disease and their potential as targets for therapy.
Structure and Function of Chemokines
Over 40 chemokines have been identified to date, most of them in the past few years. The relations among chemokines were not initially appreciated, which led to an idiosyncratic nomenclature consisting of many acronyms. When initially identified, these proteins had no known biologic . . .
The New England Journal Of Medicine