Regulation of the tissue factor gene
N Mackman - Thrombosis and haemostasis, 1997 - thieme-connect.com
N Mackman
Thrombosis and haemostasis, 1997•thieme-connect.com(Table 1). This review will summarize our current knowledge of the transcription factors that
regulate basal and inducible expression of the TF promoter. Fig. 1A shows the position of
Spl, Egr-l, NF-rB and AP-l binding sites in the human TF promoter. The identification of these
sites and their roles in the regulation of TF gene expression was detennined by a
combination of functional studies, DNase I footprinting and electrophoretic mobility shift
assays (EMSA).
regulate basal and inducible expression of the TF promoter. Fig. 1A shows the position of
Spl, Egr-l, NF-rB and AP-l binding sites in the human TF promoter. The identification of these
sites and their roles in the regulation of TF gene expression was detennined by a
combination of functional studies, DNase I footprinting and electrophoretic mobility shift
assays (EMSA).
(Table 1). This review will summarize our current knowledge of the transcription factors that regulate basal and inducible expression of the TF promoter. Fig. 1A shows the position of Spl, Egr-l, NF-rB and AP-l binding sites in the human TF promoter. The identification of these sites and their roles in the regulation of TF gene expression was detennined by a combination of functional studies, DNase I footprinting and electrophoretic mobility shift assays (EMSA).
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