Imbalanced intrahepatic expression of interleukin 12, interferon gamma, and interleukin 10 in fulminant hepatitis B
L Leifeld, S Cheng, J Ramakers, FL Dumoulin… - Hepatology, 2002 - Elsevier
In murine models, overexpression of interleukin (IL)-12 and interferon (IFN)-γ can induce
severe liver damage, whereas IL-10 has anti-inflammatory and hepatoprotective properties.
To analyze the potential role of these cytokines in human fulminant hepatitis B, we used
immunohistochemistry to study expression of IL-12, IFN-γ, and IL-10 in explant livers of 11
patients with fulminant hepatitis B, 5 patients with fulminant hepatitis due to other etiologies,
37 patients with chronic liver disease (CLD; hepatitis B virus, n= 15; hepatitis C virus, n= 10; …
severe liver damage, whereas IL-10 has anti-inflammatory and hepatoprotective properties.
To analyze the potential role of these cytokines in human fulminant hepatitis B, we used
immunohistochemistry to study expression of IL-12, IFN-γ, and IL-10 in explant livers of 11
patients with fulminant hepatitis B, 5 patients with fulminant hepatitis due to other etiologies,
37 patients with chronic liver disease (CLD; hepatitis B virus, n= 15; hepatitis C virus, n= 10; …