Goodpasture antigen of the glomerular basement membrane: localization to noncollagenous regions of type IV collagen.
J Wieslander, JF Barr, RJ Butkowski… - Proceedings of the …, 1984 - National Acad Sciences
J Wieslander, JF Barr, RJ Butkowski, SJ Edwards, P Bygren, D Heinegård, BG Hudson
Proceedings of the National Academy of Sciences, 1984•National Acad SciencesThe glomerular basement membrane antigen in Goodpasture syndrome is a collagenase-
resistant molecule with a monomer molecular weight of about 26,000. Type IV collagen
isolated from glomerular basement membrane contains collagenase-resistant sequences
within its structure. Polyacrylamide gel electrophoresis, enzyme-linked immunosorbent
assay, and chemical analysis were used to demonstrate that the collagenase-resistant
sequences of type IV collagen contain Goodpasture antigen.
resistant molecule with a monomer molecular weight of about 26,000. Type IV collagen
isolated from glomerular basement membrane contains collagenase-resistant sequences
within its structure. Polyacrylamide gel electrophoresis, enzyme-linked immunosorbent
assay, and chemical analysis were used to demonstrate that the collagenase-resistant
sequences of type IV collagen contain Goodpasture antigen.
The glomerular basement membrane antigen in Goodpasture syndrome is a collagenase-resistant molecule with a monomer molecular weight of about 26,000. Type IV collagen isolated from glomerular basement membrane contains collagenase-resistant sequences within its structure. Polyacrylamide gel electrophoresis, enzyme-linked immunosorbent assay, and chemical analysis were used to demonstrate that the collagenase-resistant sequences of type IV collagen contain Goodpasture antigen.
National Acad Sciences