Total synthesis of the-potent proteasome inhibitor epoxomicin: a useful tool for understanding proteasome biology
N Sin, KB Kim, M Elofsson, L Meng, H Auth… - Bioorganic & medicinal …, 1999 - Elsevier
Bioorganic & medicinal chemistry letters, 1999•Elsevier
Epoxomicin (1), a peptide α', β'-epoxyketone isolated from the actinomycete strain No. Q996-
17, possesses potent in vivo anti-tumor and anti-inflammatory activities. In this paper, we
report the first syntheses of epoxomicin,[3H]-epoxomicin, and a biotinylated epoxomicin
analog as well as the absolute configuration of the epoxide stereocenter. The natural
product and derivatives have permitted the first identification of the proteasome as the
specific cellular target of epoxomicin.
17, possesses potent in vivo anti-tumor and anti-inflammatory activities. In this paper, we
report the first syntheses of epoxomicin,[3H]-epoxomicin, and a biotinylated epoxomicin
analog as well as the absolute configuration of the epoxide stereocenter. The natural
product and derivatives have permitted the first identification of the proteasome as the
specific cellular target of epoxomicin.
Epoxomicin (1), a peptide α',β'-epoxyketone isolated from the actinomycete strain No.Q996-17, possesses potent in vivo anti-tumor and anti-inflammatory activities. In this paper, we report the first syntheses of epoxomicin, [3H]-epoxomicin, and a biotinylated epoxomicin analog as well as the absolute configuration of the epoxide stereocenter. The natural product and derivatives have permitted the first identification of the proteasome as the specific cellular target of epoxomicin.
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