Intracellular Ca2+ oscillations and membrane potential fluctuations in intact human T lymphocytes: role of K+ channels in Ca2+ signaling
JAH Verheugen, HPM Vijverberg - Cell calcium, 1995 - Elsevier
In intact human T lymphocytes, voltage-gated K+ [K (V)] channels and Ca2+-activated K+ [K
(Ca)] channels have been recorded using the patch clamp technique in the cell-attached
configuration. The reversal potential of the voltage-gated current with high K+ solution in the
pipette gives a measure for the cell membrane potential (VM). The open probability of the K
(Ca) channels gives a measure for intracellular Ca2+ concentration ([Ca2+] i). By
simultaneous recording of both types of K+ channels, the interaction of VM and [Ca2+] i in T …
(Ca)] channels have been recorded using the patch clamp technique in the cell-attached
configuration. The reversal potential of the voltage-gated current with high K+ solution in the
pipette gives a measure for the cell membrane potential (VM). The open probability of the K
(Ca) channels gives a measure for intracellular Ca2+ concentration ([Ca2+] i). By
simultaneous recording of both types of K+ channels, the interaction of VM and [Ca2+] i in T …