[HTML][HTML] The multifaceted mechanisms of estradiol and estrogen receptor signaling
JM Hall, JF Couse, KS Korach - Journal of biological chemistry, 2001 - ASBMB
The steroid hormone 17ß-estradiol (E2) is a key regulator of growth, differentiation, and
function in a wide array of target tissues, including the male and female reproductive tracts,
mammary gland, and skeletal and cardiovascular systems. The predominant biological
effects of E2 are mediated through two distinct intracellular receptors, ERɑ1 and ERß, each
encoded by unique genes (1) but possessing the hallmark modular structure of functional
domains characteristic of the steroid/thyroid hormone superfamily of nuclear receptors …
function in a wide array of target tissues, including the male and female reproductive tracts,
mammary gland, and skeletal and cardiovascular systems. The predominant biological
effects of E2 are mediated through two distinct intracellular receptors, ERɑ1 and ERß, each
encoded by unique genes (1) but possessing the hallmark modular structure of functional
domains characteristic of the steroid/thyroid hormone superfamily of nuclear receptors …