Tissue distribution of surfactant proteins A and D in the mouse
J Akiyama, A Hoffman, C Brown… - … of Histochemistry & …, 2002 - journals.sagepub.com
J Akiyama, A Hoffman, C Brown, L Allen, J Edmondson, F Poulain, S Hawgood
Journal of Histochemistry & Cytochemistry, 2002•journals.sagepub.comSurfactant proteins A and D, collagen-like lectins (collectins), were first isolated from the
lung. In the lung, SP-A and SP-D have roles in surfactant homeostasis and innate immunity.
In this study we show that SP-A and SP-D mRNA can be detected in a significant number of
non-pulmonary tissues but the proteins have a more limited distribution. SP-D protein was
detected in lung, uterus, ovary, and lacrimal gland, whereas SP-A protein was detected only
in the lung. The results suggest that SP-D participates in mucosal immunity throughout the …
lung. In the lung, SP-A and SP-D have roles in surfactant homeostasis and innate immunity.
In this study we show that SP-A and SP-D mRNA can be detected in a significant number of
non-pulmonary tissues but the proteins have a more limited distribution. SP-D protein was
detected in lung, uterus, ovary, and lacrimal gland, whereas SP-A protein was detected only
in the lung. The results suggest that SP-D participates in mucosal immunity throughout the …
Surfactant proteins A and D, collagen-like lectins (collectins), were first isolated from the lung. In the lung, SP-A and SP-D have roles in surfactant homeostasis and innate immunity. In this study we show that SP-A and SP-D mRNA can be detected in a significant number of non-pulmonary tissues but the proteins have a more limited distribution. SP-D protein was detected in lung, uterus, ovary, and lacrimal gland, whereas SP-A protein was detected only in the lung. The results suggest that SP-D participates in mucosal immunity throughout the body.
Sage Journals