Isolation and sequence of a cDNA clone for the rat pulmonary surfactant-associated protein (PSP-A)
K Sano, J Fisher, RJ Mason, Y Kuroki, J Schilling… - Biochemical and …, 1987 - Elsevier
K Sano, J Fisher, RJ Mason, Y Kuroki, J Schilling, B Benson, D Voelker
Biochemical and biophysical research communications, 1987•ElsevierPulmonary surfactant is composed mainly of phospholipid and two groups of apoproteins.
One of these apoproteins is a family of glycoproteins (pulmonary surfactant-associated
protein A, PSP-A). We have isolated and sequenced a cDNA clone encoding for rat PSP-A
and the full amino acid sequence has been deduced from the nucleotide sequence. The
sequence of 56 amino acids at the N-terminus of PSP-A isolated from rats treated with silica
was determined independently, and there is complete agreement with the sequence …
One of these apoproteins is a family of glycoproteins (pulmonary surfactant-associated
protein A, PSP-A). We have isolated and sequenced a cDNA clone encoding for rat PSP-A
and the full amino acid sequence has been deduced from the nucleotide sequence. The
sequence of 56 amino acids at the N-terminus of PSP-A isolated from rats treated with silica
was determined independently, and there is complete agreement with the sequence …
Summary
Pulmonary surfactant is composed mainly of phospholipid and two groups of apoproteins. One of these apoproteins is a family of glycoproteins (pulmonary surfactant-associated protein A, PSP-A). We have isolated and sequenced a cDNA clone encoding for rat PSP-A and the full amino acid sequence has been deduced from the nucleotide sequence. The sequence of 56 amino acids at the N-terminus of PSP-A isolated from rats treated with silica was determined independently, and there is complete agreement with the sequence deduced from the cDNA. Isolated rat alveolar type II cells contain two species of mRNA for this protein.
Elsevier