NK1. 1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies

I Melero, JV Johnston, WW Shufford, RS Mittler… - Cellular …, 1998 - Elsevier
The 4-1BB (CDw137) T-cell molecule is a member of the TNF receptor family and triggering
by either 4-1BB ligand or antibody ligation induces T-cell activation and growth. We have
recently demonstrated that administration of anti-4-1BB monoclonal antibodies (mAb)
induced the regression of established large tumors in several mouse models by activation of
T-cell-mediated immunity. Herein we report that selective depletion of natural killer (NK)
cells in mice by the anti-AsialoGM1 or anti-NK1. 1 antibodies completely abrogated the …